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Mucopolysaccharidosis

Mucopolysaccharidosis (MPS) is a genetic disease of cats that has a number of variants:

  • Mucopolysaccharidosis I
  • Mucopolysaccharidosis II
  • Mucopolysaccharidosis VI
  • Mucopolysaccharidosis VII

These diseases are a storage disease which results from excessive accumulation of mucopolysaccharides in lysosomes within cells throughout the cat’s body. Mucopolysaccharidoses (MPS) are lysosomal storage disorders, each caused by the deficiency of a lysosomal hydrolase needed for the degradation of mucopolysaccharide (glycosaminoglycan).

The form of MPS affects the clinical syndrome seen, although clinically it is hard to distinguish the different forms and required DNA testing to ascertain the type.

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